Yes. See MPEP 1504.05 (below). The examiner will require restriction of the invention to a single design but permit other designs to be filed in...

Can I show pictures of some of these ads in my book

The following is from the <nolo.com> site and appears to be relevant for you: WHEN IS A USE A "FAIR USE"? There are five basic rules to keep in...

Can I sue or am I entitled to royalties because this business is now using my artwork on their sign, Facebook and website?

As already noted, we would need more information to give a better answer. In general, you created a copyright in the picture when you drew it....

Is it patent infringement if the small Bio leverages this work or can they just use it for reference then patent their own tech?

I am going to make some assumptions here. First, I am presuming by "global patent" that you have filed an international application under the...

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