Please provide more details about your situation.

245 k h1b

It certainly could be, depending on your situation.

Change of status will take several months.

Travel to cancun,mexico

Suggest you check on any documents that Mexico requires.

Medical insurance during pre-green card period

Employees who leave are supposed to be offered COBRA. This question is employment not immigration.

Changed from H4 to H1B cap 2015 and got approved. Effective date approval from 10/01/2015.

Your employer needs to comply with any federal, state and local laws regarding payment of salary.

Deadline documents

Missing a deadline certainly can lead to denial.

In case of change of status from H4 to H1B, do I need to start my employment from Oct 1st itself?

Best to work with company attorney.

H1 RFE - regarding requirement for a degree in a specific specialty. How to respond to this? Please help.

Suggest you search monster.com for similar jobs. Also consider expert opinion letter.

H1 RFE - regarding requirement for a degree in a specific specialty. How to respond to this? Please help.

Suggest you search monster.com for similar jobs. Also consider expert opinion letter.