TN visa expires in 2013 but I 94 will expire in 2015. Do I need to renew TN visa this year or can I wait until 2015?

Visa is travel document. You need a valid visa to travel back to the U.S.

H4-F1-OPT- India Travel, No F1 Visa stamp so far, Can I travel to India?

Travel on OPT is not recommended.

Travel to India during L to H conversion

If you depart U.S. the COS is considered abandoned by the USCIS.

My father in law is a US citizen filed I130 petition for my Wife in June 2010 to my wife who is married and over 21 years

It is best if you retain a competent attorney to respond to RFE(s) of this nature. It will be money well spent. If you try to figure this out...

Can i submit multiple requests for h1-b transfer for multiple companies at the same time? And then chose one of the companies?

Prospective employers may petition in your behalf.

Have applied for B2 VISA Extn. thru ELIS for parents. Would it be OK to submit additional evidence while decision is pending ?

I don't see how it will help. When you filed for extension the reason was tourism. USCIS looks at the application on the date of filing and will...

Depends on how long your association with the company.

Invoking AC21-Is it safe

I don't see anything unusual and/ or cause for concern.

Will I face issues if my spouse worked without a valid EAD for over 180 days

I agree with my colleagues.

Do you have to be employed to maintain and renew your Employment Authorization Document?

How long has it been since the I-485 was filed?