OXYCODONE Oxycodone is an opioid synthesized from opium-derived thebaine. It was developed in 1916 in Germany by Freund and Speyer of the University of Frankfurt, only a few years after pharmaceutical company Bayer had stopped the mass production of heroin due to addiction and abuse. It was hoped that a thebaine-derived drug would retain the analgesic effects of morphine and heroin with less addiction. The first clinical use of the drug was documented in 1917. The drug was first introduced to the US market in 1939 and is the active ingredient in a number of pain medications commonly prescribed for the relief of moderate to severe pain, either with inert binders (e.g. OxyContin) or supplemental analgesics such as paracetamol (acetaminophen), (e.g. Percocet, Endocet, Tylox, Roxicet) or aspirin (e.g. Percodan, Endodan, Roxiprin). More recently, ibuprofen has been added to oxycodone under the name Combunox.