Technically, there is an automatic stay upon filing and service of domestic relations summons. But a party can the n petition the court for permission to sell the property.
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A lot more information is required to fully analyze the situation. He should consult a local attorney ASAP and discuss the matter in detail.
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There are many issues to digest in your question. I realize that you had limited space on this forum but a decent answer cannot be given here other than I would suggest that your son file for divorce and petition the court to allow the sale. Considering neither are living there, it is a good possibility. He cannot do any major financial dealing without leave from court.
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