Based on the limited amount of information, an H1B is your best bet unless you are willing to continue studying or are eligible for OPT or are considering lawful marriage to a US citizen. Also depending on where you are from you may qualify for an E2 investor visa or a TN visa.
If you can find a job, you can start out with OPT and hopefully they will sponsor you for an H-1B before the OPT runs out.
There could be other options, like maybe starting up a business here, but I think your best bet is to talk in more detail with an immigration attorney to see exactly what options are there.
As you mentioned there is the H1, perhaps investment visa, true marriage to US citizen. You mentioned difficulties in the home country - asylum may be an option as well. You should consult with an attorney to discuss in detail.
Samuel Ouya Maina, Esq. 415.391.6612 email@example.com Law Offices of S. Ouya Maina, PC 332 Pine Street, Suite 707 San Francisco, CA 94104