If you are a US Citizen you can file a two step package for your wife, providing she meets all eligibility requirements. This would consist of I-130 petition and I-485 filed concurrently. There are other forms and documents that need to be filed. In order to make sure the processing goes smoothly, kindly counsel with an immigration attorney. Best of luck to you and your spouse.
This answer does not constitute legal advice and is for general information purposes only. It does not constitute an attorney-client relationship. The information provided is based upon the information given by the requestor. In order to provide the requestor with legal advice, a legal consultation would be necessary and at such times all relevant information would need to be disclosed by requestor.
Since she is here you will be filing an adjustment of status for her and this question has been answered here several times just do a search for it.
I-130 and I-485 are the principal forms; follow their filing instructions closely. G-325A and I-765 are other forms that typically accompany them. In any event, I recommend speaking with qualified legal counsel.
If you are a US citizen and she does not have any other grounds of inadmissibility, then she can adjust her status here in the US. Some courts have stated that the selection of forms constitutes specific legal advice, so it would be best to consult with an attorney to make sure that you get all of the forms that she will need.
This answer is intended to provide general information and should not to be construed as legal advice pertaining to a particular situation or relied upon as such. You should have your specific situation reviewed by an attorney.