It is impossible to know without many more details. Usually publicly traded companies have already figured out those numbers based on a percentage of the wages paid. Perhaps a call to HR could get you that information. I have seen benefits being worth from about an additional10% to as much as an additional 35% of the salary paid.
Ultimately, the number will be negotiated. Good luck to you.
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A forensic accountant who understands employment law can also do this analysis. Or, there is a program called wrongful termination economist that you can buy.
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You may want to consult with an employment attorney to negotiate the terms of your separation agreement with your employer.
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If this is a "severance" amount or a settlement of an employment claim (i.e. wrongful termination, breach of contract, etc.) I am wondering if you are asking about tax implications of receiving such amount. Generally as part of any settlement a Release Agreement is worked out which protects both the expectations of the employer and ex-employee. (confidentiality, employment references, tax tratment, etc.) It is not atypical to include a provision to provide for "characterization" of the settlement payment. Typically, this includes whether all or some of the sum will be taxable or not and sets out the reporting issues. Although the taxing authorities are not bound by the parties agreement, a well documented recital may be given weight in respecting such tax characterization. If you are represented by counsel, question them on this issue. If not, you may wish to consult with an experienced attorney who can help you "document" your expectations and hopefully prevent surprises that may fall out in the future.