Are you asking if it is illegal to buy spices (as in salt, pepper, oregano, etc...) online? If that is the question, as long as it is coming from a legal source that is fine. If you mean something else by the word "spice" I have no idea.
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If the product is imported, then advance notification to the Food and Drug Administration may be required. FDA testing and labeling requirements may apply to items intended to be resold, whether domestically produced or imported. See https://help.cbp.gov/app/answers/detail/a_id/337/~/importing-tea,-coffee-and-spices-for-commercial-purposes
Yes. It is illegal to buy synthetic marijuana.
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