It depends on your definition of "safe." Traveling outside the US, always carries some risk. I have represented individuals who had all the proper visas and the proper purpose for entering the US, yet were denied entry.
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It's impossible for someone to answer this question. Technically, to return to the US, you'll need a current I-20 with a travel designation from your current school, your current OPT card and a valid F-1 visa stamp in your passport (even if it's for a different school or program). But the officer at the airport may or may not admit you to the US based on a long list of factors, including prior immigration violations, criminal issues, etc. You should consult with an experienced immigration attorney to determine if you have a likelihood of experiencing any issues when you travel.
Why not? I hope you home country is safe. Will you be allowed to return on your visa? If it is still valid when you return and you are enrolled in the MBA, I think you should be fine.
NYC EXPERIENCED IMMIGRATION ATTORNEYS www.myattorneyusa.com; email: email@example.com; Phone: (866) 456-8654; Fax: 212-964-0440; Cell: 212-202-0325. The information contained in this answer is provided for informational purposes only, and should not be construed as legal advice on any subject matter.