From a quick internet search, it would appear that 222 is a type of pill. This pill may contain codeine, which is a controlled substance in the United States. You would be taking a chance of getting in trouble by bringing this into the United States.
No. It's not legal to bring these 222 tablets (aspirin with codeine) from Canada into the US without a valid doctor's prescription and additional strict limitations.
Don't even think about trying to get something like this past the customs officers. I work in both criminal law and immigration deportation and I assure you that the US customs officers are quite good at what they do.
What you can bring back at a real bargain from Canada are cases of wine. The duty is only like .10 or .20 a bottle.
There is no attorney-client relationship formed in the absence of a counter-signed agreement between Brent De Young and any reader. Anything I write is not be relied upon as specific legal advice, but should instead give you a sense of urgency to hire an experienced attorney to advise you. I am not available to be retained in any pending criminal matter or for any EOIR "immigration court" matters. Immigration or 1326 counsel seeking an experienced PCR attorney may contact me directly.