General rule is voluntary leaving is a disqualified. There are five exceptions. One is leaving on medical advice. If you are physically unable to do this job and a physician says so in writing and you are ready willing and able to do other work, you may be eligible. See the doc first. Voluntary leaving is tough to overcome.
This will depend on how much your job is changing from the duties you have been performing for the last few years, and whether the changes to your job are reasonable business decisions or perhaps intended to force you out. Generally speaking, it might be hard to get unemployment in this case, but it depends on the 2 points i mentioned above
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