An appeal can always be filed provided it is still within the time frame and there is an appealable issue. This could only be determined after an experienced appellate attorney carefully reviews the case file and all transcripts. A motion to set aside the conviction is an expungement and would not apply to this case as murder cannot be expunged or set aside. He would not be eligible for parole until he served his minimum sentence as required by the truth in sentencing act. If there is nothing that can be appealed, then his only other chance would be a partner or a commutation from the governor which is rare. An appellate attorney should at least review the case to see if there are any options left.
First, I would NOT recommend you filing the motion. If there are preserved, appealable issues, and/or substantial deviations in proceedure, arbitratary decisions by the court, or evidence that there were errors in the jury, timely appeal may be made. Hopefully, you will invest in a criminal appeals attorney.
You absolutely need a criminal defense appeals attorney.
The information provided in this answer does not create an attorney-client relationship and is not considered to be legal advice.