Failure to handle a matter entrusted to an attorney is one of the major sources of complaints to state bars. I would go to the expense and inconvenience of trying to call your attorney's office during business hours. Maybe she changed her e-mail account. If you still cannot get a hold of her you need to hire a new attorney. From your account of events you would be justified in filing a complaint with your state bar, assuming the problem is her unavailability by more than only the e-mail method of contact.