My brother is due to be sentenced for a sexual federal crime. He has mental and intellucual issues, how can we appeal?

An appeal in this circumstance depends upon a lot of things, one of which is whether your brother preserved his appeal rights in the case. If so he should fully go over all details with his attorney to formulate an appeal approach. This will be difficult and your brother should not try it without the attorney.

Check with his lawyer to discuss more of the details.

Good luck to you.

God bless.

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Yes its important to discuss any facts, e.g. his mental problems, learning disabilities, which might bear on 18 USC 3553, with his attorney.

Your post does not suggest that you are dissatisifed with his attorney, just the fact that he was convicted. Make sure you discuss with his attorney, what might be the issues on appeal. (If he was convicted, his appeal would be to the Eleventh Circuit court of appeals in Atlanta.)

Good luck.