If my wife has been deported for the 2nd time, is there anything that can be done to get her back into the U.S.

Your wife is in a pretty bad predicament. For the most part either one of those violations makes her inadmissible for a minimum of 10 years, possibly more. She may however, apply for a waiver to renter the country (depending on the specifics of the case), but I do not see much chance for success. Of course, everything is dependent on the specific facts of the situtation (including her conviction and unlawful reentry).

Based on the drug conviction alone, she may be considered an aggravated felon and inadmissible for life. You should consult with an immigration attorney who is skilled in criminal deportation cases and have him/her assess her history and potential for any sort of waiver of inadmissibility. It is important to provide any attorney with certified copies of the journal entry of conviction and sentence for all criminal issues. This will help the attorney to properly assess the immigration consequences. Additionally, you should inform the attorney of your wife's alien registration number so he/she can determine the immigration/deportation history.

Attorneys who practice immigration law are practicing federal law and therefore you can hire an attorney from anywhere in the country (as long as he/she is licensed).