That all depends on your age, the amounts you contributed, the nature of the retirement plans and the hardships.
The IRS does recognize some exceptions to the early retirement penalty problem (see http://www.irs.gov/Retirement-Plans/Plan-Participant,-Employee/Retirement-Topics---Tax-on-Early-Distributions).
It may also be possible to setup a self-directed IRA, roll your retirement funds to this, and then access those funds for specific business purposes under properly structured vehicles. But doing this is not a do-it-yourself process by any means.
Depending on what direction you decide to go, you'll like need the services of an attorney to assist.
Evan A. Nielsen is licensed to practice law in California and handles federal tax matters throughout the U.S. The information provided here is for educational purposes only and is not intended as legal advice for a particular matter. This response does not create any attorney-client relationship with the author. For specific advice about your particular situation, please consult an attorney.
The withdrawals will be subject to tax and possibly a 10% early withdrawal penalty. The IRS is pretty strict on waiving the 10% penalty based on hardship, and based on the minimal facts presented it doesn't seem you would qualify for a hardship withdrawal. You will want to speak with a attorney or CPA prior to withdrawing the monies so that you have a better understanding of the liabilities incur.
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