There is no "E" visa treaty between the U.S. and India at present. An immigrant petition filed by your sister will take 10-14 years to process and cannot enable you to remain in the US in the meantime. The hotel she owns will not be of any help since any job they might offer you for working at the hotel will not be in a position necessitating a university degree. Besides, there are no more H-1B visas available now until October 2014.
You will not qualify for an L-1b visa through the motel either, and let's not even mention the L-1A visa, since you have not worked for at least a year in the parent company or affiliate owning this hotel in India.
The only possible alternative is if they could offer you an H-3 Training visa position from the hotel: need to consult with an immigration lawyer to examine that possibility. Of course, you could always end up falling in love and marrying a nice Hindi girl with an American passport your sister could introduce you to.. You could then file for a green card right away.